USMLE coverage

From first principles to patient management.

Prepare across the full USMLE journey with detailed coverage for Step 1, Step 2 CK, and Step 3. StepSpirit connects mechanisms, clinical reasoning, diagnosis, management, prevention, and review so students can see the complete path instead of studying scattered topics.

Choose your exam See how you’ll study

Build the foundation

USMLE Step 1

Connect the basic sciences to disease mechanisms, clinical findings, diagnostic clues, and the way board questions test them.

Step 1 is not only memorizing facts. StepSpirit helps students understand why a disease happens, how it changes normal physiology, which lab or imaging findings appear, and how that mechanism becomes a board-style question. The goal is to make each topic useful when a vignette asks for the next concept, not just the name of the diagnosis.

You build a strong medical foundation that makes later clinical reasoning easier instead of starting over for Step 2 CK.

Subjects covered

Pathology & pathophysiology
Pharmacology
Physiology
Microbiology & immunology
Biochemistry & genetics
Anatomy, embryology & neuroanatomy
Behavioral science
Biostatistics & epidemiology

What students practice

Mechanisms of disease, inflammation, neoplasia, hemodynamics, and cell injury
Drug mechanisms, adverse effects, contraindications, interactions, and autonomic pharmacology
Bacterial, viral, fungal, parasitic, and immunologic patterns that show up in clinical vignettes
Metabolism, genetics, inheritance patterns, molecular biology, and nutritional deficiencies
Cardio, pulmonary, renal, GI, endocrine, reproductive, neuro, musculoskeletal, skin, blood, and immune systems
Graphs, experiments, ethics, communication, probability, sensitivity, specificity, and study design

Think clinically

USMLE Step 2 CK

Practice diagnosis, next-best-step decisions, treatment, prevention, and patient safety across the major clerkships.

Step 2 CK asks whether you can move from symptoms to action. StepSpirit is built around clinical decisions: what is the most likely diagnosis, which test comes first, when treatment should not wait, how to screen, when to reassure, and how to avoid unsafe management. The content helps you compare similar presentations so you can choose the best answer when several options look reasonable.

You learn to handle clinical vignettes with a structured approach: stabilize, diagnose, treat, prevent, and follow up.

Subjects covered

Internal medicine
Surgery
Pediatrics
Obstetrics & gynecology
Psychiatry
Emergency medicine
Family medicine & ambulatory care
Preventive care, ethics & quality improvement

Manage the patient

USMLE Step 3

Move from recognizing disease to choosing safe, complete management over time in outpatient, emergency, and inpatient settings.

Step 3 tests whether you can manage patients like a physician. StepSpirit emphasizes longitudinal care: initial stabilization, diagnostic sequencing, treatment selection, monitoring response, adjusting plans, counseling, prevention, and avoiding harm. The goal is to help you think beyond one answer and understand what should happen next for the patient.

You practice the judgment needed for independent clinical management, continuity of care, and risk-based decisions.

Subjects covered

Acute care
Chronic disease management
Diagnosis & treatment
Prognosis & risk
Prevention & screening
Medication safety
Follow-up and monitoring
Advanced clinical judgment

What makes the coverage useful

Build connections across the whole exam blueprint.

Questions rarely live in one box. A cardiovascular case can test physiology, pharmacology, pathology, emergency care, prevention, and long-term management. StepSpirit helps students connect those layers across every major system and discipline.

Cardiovascular

Heart failure, arrhythmias, murmurs, ischemia, congenital lesions, hypertension, shock, vascular disease, ECG clues, and medication choices.

Pulmonary

Obstructive and restrictive disease, respiratory failure, infections, embolism, pleural disease, acid-base physiology, oxygenation, and ventilation.

Renal

Electrolytes, acid-base disorders, nephritic and nephrotic patterns, acute kidney injury, chronic kidney disease, dialysis, and hypertension links.

Gastrointestinal

Abdominal pain, liver disease, biliary disease, pancreatic disease, bleeding, malabsorption, inflammatory bowel disease, and GI cancers.

Endocrine

Diabetes, thyroid disease, adrenal disorders, pituitary disease, calcium problems, reproductive hormones, endocrine emergencies, and treatment monitoring.

Reproductive

Pregnancy, labor, postpartum care, menstrual problems, infertility, contraception, menopause, gynecologic cancers, and sexually transmitted infections.

Neurology

Stroke, seizures, headache, weakness, movement disorders, neuropathies, spinal cord lesions, neuroanatomy localization, and emergency management.

Psychiatry

Mood, anxiety, psychosis, personality disorders, substance use, suicide risk, capacity, therapy choices, and medication adverse effects.

Musculoskeletal

Arthritis, trauma, bone disease, soft tissue injuries, autoimmune patterns, pediatric orthopedics, and pain management.

Dermatology

Rashes, infections, autoimmune skin disease, drug eruptions, malignancy warning signs, pediatric skin findings, and biopsy clues.

Hematology

Anemias, bleeding disorders, thrombosis, transfusion reactions, anticoagulation, leukemias, lymphomas, and smear interpretation.

Ready when you are

Tell us which USMLE step you are preparing for.

We’ll help you confirm the right access option and send your payment link directly.

Message StepSpirit

Loading StepSpirit

From first principles to patient management.

USMLE Step 1

Subjects covered

What students practice

USMLE Step 2 CK

Subjects covered

USMLE Step 3

Subjects covered

More than a topic list.

Build connections across the whole exam blueprint.

Cardiovascular

Pulmonary

Renal

Gastrointestinal

Endocrine

Reproductive

Neurology

Psychiatry

Musculoskeletal

Dermatology

Hematology

Tell us which USMLE step you are preparing for.

What students practice

What students practice

Oncology

Immunology

Infectious Disease

Biostatistics

Ethics